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Escherichia coli serotype O9a O-antigen biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
GDP-mannose + [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]n-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol <=> [alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)]n-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + GDP + H+ 2.4.1.371 polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 2,3-alpha-mannosylpolymerase

UDP-N-acetyl-D-glucosamine + undecaprenyl_phosphate <=> N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol + UMP 2.7.8.33 UDP-N-acetylglucosamine---undecaprenyl-phosphate N-acetylglucosaminephosphotransferase

GDP-mannose + alpha-D-mannosyl-(1rarr3)-alpha-D-mannosyl-(1rarr3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol <=> alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol + GDP + H+ 2.4.1.349 mannosyl-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase

GDP-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol <=> alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol + GDP + H+ 2.4.1.348 N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase

GDP-mannose + alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol <=> [alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)]n-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + GDP + H+ 2.4.1.371 polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 2,3-alpha-mannosylpolymerase

GDP-mannose + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol <=> alpha-D-mannosyl-(1rarr3)-alpha-D-mannosyl-(1rarr3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol + GDP + H+ 2.4.1.349 mannosyl-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase

ATP + alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-[alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)]n-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol <=> ADP + 3-O-phospho-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr3)]n-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + H+ 2.7.1.181 polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol kinase

S-adenosyl-L-methionine + 3-O-phospho-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr3)]n-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol <=> S-adenosyl-L-homocysteine + 3-O-methylphospho-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr3)-[alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr3)]n-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol 2.1.1.294 3-O-phospho-polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 3-phospho-methyltransferase

GDP-mannose + [alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)]n-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol <=> alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)-[alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr2)-alpha-D-Man-(1rarr2)]n-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr3)-alpha-D-Man-(1rarr3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol + GDP + H+ 2.4.1.371 polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 2,3-alpha-mannosylpolymerase

Visualization of the pathway